ANTI-PROLIFERATIVE ACTIVITIES OF 32 MALAYSIAN PLANT SPECIES IN BREAST CANCER CELL LINES

Abstract

NURHANAN, M. Y., ASIAH, O., MOHD ILHAM, M. A., SITI SYARIFAH, M. M., NORHAYATI, I. & LILI SAHIRA, H. 2008. Anti-proliferative activities of 32 Malaysian plant species in breast cancer cell lines. Anti-proliferative activities of 143 crude extracts obtained from 32 plants collected from the rain forests of Pahang, Malaysia, were evaluated in two breast cancer cell lines, i.e. MCF-7 and T47D, obtained from the American Type Culture Collection, USA. The objective of this study was to bioprospect a list of plants to find out their potential to be developed into anti-cancer drug(s), by means of bioassay guided isolation procedure. After performing sulforhodamine-B assay, 13  crude  extracts from 11 plant species were found to have active anti-proliferative effects (IC,„s 100 pg ml ’) .